diff --git a/Lib/test/test_interpreters/test_channels.py b/Lib/test/test_interpreters/test_channels.py
index 52827357078b85..13af52d1d645e7 100644
--- a/Lib/test/test_interpreters/test_channels.py
+++ b/Lib/test/test_interpreters/test_channels.py
@@ -1,4 +1,3 @@
-import importlib
 import pickle
 import threading
 from textwrap import dedent
@@ -28,7 +27,12 @@ class LowLevelTests(TestBase):
 
     def test_highlevel_reloaded(self):
         # See gh-115490 (https://github.com/python/cpython/issues/115490).
-        importlib.reload(channels)
+        interp = interpreters.create()
+        interp.exec(dedent(f"""
+            import importlib
+            from test.support import channels
+            importlib.reload(channels)
+            """));
 
 
 class TestChannels(TestBase):
diff --git a/Lib/test/test_interpreters/test_queues.py b/Lib/test/test_interpreters/test_queues.py
index 77334aea3836b9..d415cb0e1f0ab9 100644
--- a/Lib/test/test_interpreters/test_queues.py
+++ b/Lib/test/test_interpreters/test_queues.py
@@ -1,4 +1,3 @@
-import importlib
 import pickle
 import threading
 from textwrap import dedent
@@ -39,7 +38,12 @@ class LowLevelTests(TestBase):
 
     def test_highlevel_reloaded(self):
         # See gh-115490 (https://github.com/python/cpython/issues/115490).
-        importlib.reload(queues)
+        interp = interpreters.create()
+        interp.exec(dedent(f"""
+            import importlib
+            from concurrent.interpreters import _queues as queues
+            importlib.reload(queues)
+            """));
 
     def test_create_destroy(self):
         qid = _queues.create(2, REPLACE, -1)
diff --git a/Misc/NEWS.d/next/Tests/2026-01-21-02-03-31.gh-issue-142414.CfcgiR.rst b/Misc/NEWS.d/next/Tests/2026-01-21-02-03-31.gh-issue-142414.CfcgiR.rst
new file mode 100644
index 00000000000000..6d4cbfc490a17d
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2026-01-21-02-03-31.gh-issue-142414.CfcgiR.rst
@@ -0,0 +1,2 @@
+Isolate reloading modules in test_interpreters to avoid having broken
+references.