diff --git a/Doc/library/subprocess.rst b/Doc/library/subprocess.rst
index b8dfcc310771fe..3b3cb7b946c23a 100644
--- a/Doc/library/subprocess.rst
+++ b/Doc/library/subprocess.rst
@@ -803,14 +803,29 @@ Instances of the :class:`Popen` class have the following methods:
 
    .. note::
 
-      When the ``timeout`` parameter is not ``None``, then (on POSIX) the
-      function is implemented using a busy loop (non-blocking call and short
-      sleeps). Use the :mod:`asyncio` module for an asynchronous wait: see
+      When ``timeout`` is not ``None`` and the platform supports it, an
+      efficient event-driven mechanism is used to wait for process termination:
+
+      - Linux ≥= 5.3 uses :func:`os.pidfd_open` + :func:`select.poll`
+      - macOS and other BSD variants use :func:`select.kqueue` +
+        ``KQ_FILTER_PROC`` + ``KQ_NOTE_EXIT``
+      - Windows uses ``WaitForSingleObject``
+
+      If none of these mechanisms are available, the function falls back to a
+      busy loop (non-blocking call and short sleeps).
+
+   .. note::
+
+      Use the :mod:`asyncio` module for an asynchronous wait: see
       :class:`asyncio.create_subprocess_exec`.
 
    .. versionchanged:: 3.3
       *timeout* was added.
 
+   .. versionchanged:: 3.15
+      if *timeout* is not ``None``, use efficient event-driven implementation
+      on Linux >= 5.3 and macOS / BSD.
+
 .. method:: Popen.communicate(input=None, timeout=None)
 
    Interact with process: Send data to stdin.  Read data from stdout and stderr,
diff --git a/Doc/whatsnew/3.15.rst b/Doc/whatsnew/3.15.rst
index b7a27d5db63875..9fd681f704ee8a 100644
--- a/Doc/whatsnew/3.15.rst
+++ b/Doc/whatsnew/3.15.rst
@@ -736,6 +736,20 @@ ssl
 
    (Contributed by Ron Frederick in :gh:`138252`.)
 
+subprocess
+----------
+
+* :meth:`subprocess.Popen.wait`: when ``timeout`` is not ``None`` and the
+  platform supports it, an efficient event-driven mechanism is used to wait for
+  process termination:
+
+  - Linux ≥= 5.3 uses :func:`os.pidfd_open` + :func:`select.poll`
+  - macOS and other BSD variants use :func:`select.kqueue` + ``KQ_FILTER_PROC`` + ``KQ_NOTE_EXIT``
+  - Windows keeps using ``WaitForSingleObject`` (unchanged)
+
+  If none of these mechanisms are available, the function falls back to the
+  traditional busy loop (non-blocking call and short sleeps).
+  (Contributed by Giampaolo Rodola in :gh:`83069`).
 
 sys
 ---
diff --git a/Lib/subprocess.py b/Lib/subprocess.py
index 3cebd7883fcf29..43d352aec846a3 100644
--- a/Lib/subprocess.py
+++ b/Lib/subprocess.py
@@ -51,6 +51,8 @@
 import threading
 import warnings
 import contextlib
+import math
+import select
 from time import monotonic as _time
 import types
 
@@ -121,7 +123,6 @@ class _del_safe:
             WNOHANG = None
             ECHILD = errno.ECHILD
 
-    import select
     import selectors
 
 
@@ -748,6 +749,63 @@ def _use_posix_spawn():
     return False
 
 
+def _can_use_pidfd_open():
+    # Availability: Linux >= 5.3
+    if not hasattr(os, "pidfd_open"):
+        return False
+    try:
+        pidfd = os.pidfd_open(os.getpid(), 0)
+    except OSError as err:
+        if err.errno in {errno.EMFILE, errno.ENFILE}:
+            # transitory 'too many open files'
+            return True
+        # likely blocked by security policy like SECCOMP (EPERM,
+        # EACCES, ENOSYS)
+        return False
+    else:
+        os.close(pidfd)
+        return True
+
+
+def _can_use_kqueue():
+    # Availability: macOS, BSD
+    if not all(
+        hasattr(select, x)
+        for x in (
+            "kqueue",
+            "KQ_EV_ADD",
+            "KQ_EV_ONESHOT",
+            "KQ_FILTER_PROC",
+            "KQ_NOTE_EXIT",
+        )
+    ):
+        return False
+
+    kq = None
+    try:
+        kq = select.kqueue()
+        kev = select.kevent(
+            os.getpid(),
+            filter=select.KQ_FILTER_PROC,
+            flags=select.KQ_EV_ADD | select.KQ_EV_ONESHOT,
+            fflags=select.KQ_NOTE_EXIT,
+        )
+        events = kq.control([kev], 1, 0)
+        return True
+    except OSError as err:
+        if err.errno in {errno.EMFILE, errno.ENFILE}:
+            # transitory 'too many open files'
+            return True
+        return False
+    finally:
+        if kq is not None:
+            kq.close()
+
+
+_CAN_USE_PIDFD_OPEN = _can_use_pidfd_open()
+_CAN_USE_KQUEUE = _can_use_kqueue()
+
+
 # These are primarily fail-safe knobs for negatives. A True value does not
 # guarantee the given libc/syscall API will be used.
 _USE_POSIX_SPAWN = _use_posix_spawn()
@@ -2046,14 +2104,100 @@ def _try_wait(self, wait_flags):
                 sts = 0
             return (pid, sts)
 
+        def _wait_pidfd(self, timeout):
+            """Wait for PID to terminate using pidfd_open() + poll().
+            Linux >= 5.3 only.
+            """
+            if not _CAN_USE_PIDFD_OPEN:
+                return False
+            try:
+                pidfd = os.pidfd_open(self.pid, 0)
+            except OSError:
+                # May be:
+                # - ESRCH: no such process
+                # - EMFILE, ENFILE: too many open files (usually 1024)
+                # - ENODEV: anonymous inode filesystem not supported
+                # - EPERM, EACCES, ENOSYS: undocumented; may happen if
+                #   blocked by security policy like SECCOMP
+                return False
+
+            try:
+                poller = select.poll()
+                poller.register(pidfd, select.POLLIN)
+                events = poller.poll(math.ceil(timeout * 1000))
+                if not events:
+                    raise TimeoutExpired(self.args, timeout)
+                return True
+            finally:
+                os.close(pidfd)
+
+        def _wait_kqueue(self, timeout):
+            """Wait for PID to terminate using kqueue(). macOS and BSD only."""
+            if not _CAN_USE_KQUEUE:
+                return False
+            try:
+                kq = select.kqueue()
+            except OSError:
+                # likely EMFILE / ENFILE (too many open files)
+                return False
+
+            try:
+                kev = select.kevent(
+                    self.pid,
+                    filter=select.KQ_FILTER_PROC,
+                    flags=select.KQ_EV_ADD | select.KQ_EV_ONESHOT,
+                    fflags=select.KQ_NOTE_EXIT,
+                )
+                try:
+                    events = kq.control([kev], 1, timeout)  # wait
+                except OSError as err:  # should never happen
+                    return False
+                else:
+                    if not events:
+                        raise TimeoutExpired(self.args, timeout)
+                    return True
+            finally:
+                kq.close()
 
         def _wait(self, timeout):
-            """Internal implementation of wait() on POSIX."""
+            """Internal implementation of wait() on POSIX.
+
+            Uses efficient pidfd_open() + poll() on Linux or kqueue()
+            on macOS/BSD when available. Falls back to polling
+            waitpid(WNOHANG) otherwise.
+            """
             if self.returncode is not None:
                 return self.returncode
 
             if timeout is not None:
-                endtime = _time() + timeout
+                if timeout < 0:
+                    raise TimeoutExpired(self.args, timeout)
+                started = _time()
+                endtime = started + timeout
+
+                # Try efficient wait first.
+                if self._wait_pidfd(timeout) or self._wait_kqueue(timeout):
+                    # Process is gone. At this point os.waitpid(pid, 0)
+                    # will return immediately, but in very rare races
+                    # the PID may have been reused.
+                    # os.waitpid(pid, WNOHANG) ensures we attempt a
+                    # non-blocking reap without blocking indefinitely.
+                    with self._waitpid_lock:
+                        if self.returncode is not None:
+                            return self.returncode  # Another thread waited.
+                        (pid, sts) = self._try_wait(os.WNOHANG)
+                        assert pid == self.pid or pid == 0
+                        if pid == self.pid:
+                            self._handle_exitstatus(sts)
+                            return self.returncode
+                        # os.waitpid(pid, WNOHANG) returned 0 instead
+                        # of our PID, meaning PID has not yet exited,
+                        # even though poll() / kqueue() said so. Very
+                        # rare and mostly theoretical. Fallback to busy
+                        # polling.
+                        elapsed = _time() - started
+                        endtime -= elapsed
+
                 # Enter a busy loop if we have a timeout.  This busy loop was
                 # cribbed from Lib/threading.py in Thread.wait() at r71065.
                 delay = 0.0005 # 500 us -> initial delay of 1 ms
@@ -2085,6 +2229,7 @@ def _wait(self, timeout):
                         # http://bugs.python.org/issue14396.
                         if pid == self.pid:
                             self._handle_exitstatus(sts)
+
             return self.returncode
 
 
diff --git a/Lib/test/test_subprocess.py b/Lib/test/test_subprocess.py
index 806a1e3fa303eb..cbf909a6e20636 100644
--- a/Lib/test/test_subprocess.py
+++ b/Lib/test/test_subprocess.py
@@ -1423,6 +1423,8 @@ def test_wait(self):
     def test_wait_timeout(self):
         p = subprocess.Popen([sys.executable,
                               "-c", "import time; time.sleep(0.3)"])
+        with self.assertRaises(subprocess.TimeoutExpired) as c:
+            p.wait(timeout=0)
         with self.assertRaises(subprocess.TimeoutExpired) as c:
             p.wait(timeout=0.0001)
         self.assertIn("0.0001", str(c.exception))  # For coverage of __str__.
@@ -4094,5 +4096,125 @@ def test_broken_pipe_cleanup(self):
         self.assertTrue(proc.stdin.closed)
 
 
+
+class FastWaitTestCase(BaseTestCase):
+    """Tests for efficient (pidfd_open() + poll() / kqueue()) process
+    waiting in subprocess.Popen.wait().
+    """
+    CAN_USE_PIDFD_OPEN = subprocess._CAN_USE_PIDFD_OPEN
+    CAN_USE_KQUEUE = subprocess._CAN_USE_KQUEUE
+
+    def assert_fast_waitpid_error(self, patch_point):
+        # Emulate a case where pidfd_open() or kqueue() fails.
+        # Busy-poll wait should be used as fallback.
+        exc = OSError(errno.EMFILE, os.strerror(errno.EMFILE))
+        with mock.patch(patch_point, side_effect=exc) as m:
+            p = subprocess.Popen([sys.executable,
+                                  "-c", "import time; time.sleep(0.3)"])
+            with self.assertRaises(subprocess.TimeoutExpired):
+                p.wait(timeout=0.0001)
+            self.assertEqual(p.wait(timeout=support.SHORT_TIMEOUT), 0)
+        assert m.called
+
+    @unittest.skipIf(not CAN_USE_PIDFD_OPEN, reason="needs pidfd_open()")
+    def test_wait_pidfd_open_error(self):
+        self.assert_fast_waitpid_error("os.pidfd_open")
+
+    @unittest.skipIf(not CAN_USE_KQUEUE, reason="needs kqueue() for proc")
+    def test_wait_kqueue_error(self):
+        self.assert_fast_waitpid_error("select.kqueue")
+
+    @unittest.skipIf(not CAN_USE_KQUEUE, reason="needs kqueue() for proc")
+    def test_kqueue_control_error(self):
+        # Emulate a case where kqueue.control() fails. Busy-poll wait
+        # should be used as fallback.
+        p = subprocess.Popen([sys.executable,
+                              "-c", "import time; time.sleep(0.3)"])
+        kq_mock = mock.Mock()
+        kq_mock.control.side_effect = OSError(
+            errno.EPERM, os.strerror(errno.EPERM)
+        )
+        kq_mock.close = mock.Mock()
+
+        with mock.patch("select.kqueue", return_value=kq_mock) as m:
+            with self.assertRaises(subprocess.TimeoutExpired):
+                p.wait(timeout=0.0001)
+            self.assertEqual(p.wait(timeout=support.SHORT_TIMEOUT), 0)
+        assert m.called
+
+    def assert_wait_race_condition(self, patch_target, real_func):
+        # Call pidfd_open() / kqueue(), then terminate the process.
+        # Make sure that the wait call (poll() / kqueue.control())
+        # still works for a terminated PID.
+        p = subprocess.Popen([sys.executable,
+                              "-c", "import time; time.sleep(0.3)"])
+
+        def wrapper(*args, **kwargs):
+            ret = real_func(*args, **kwargs)
+            try:
+                os.kill(p.pid, signal.SIGTERM)
+                os.waitpid(p.pid, 0)
+            except OSError:
+                pass
+            return ret
+
+        with mock.patch(patch_target, side_effect=wrapper) as m:
+            status = p.wait(timeout=support.SHORT_TIMEOUT)
+        assert m.called
+        self.assertEqual(status, 0)
+
+    @unittest.skipIf(not CAN_USE_PIDFD_OPEN, reason="needs pidfd_open()")
+    def test_pidfd_open_race(self):
+        self.assert_wait_race_condition("os.pidfd_open", os.pidfd_open)
+
+    @unittest.skipIf(not CAN_USE_KQUEUE, reason="needs kqueue() for proc")
+    def test_kqueue_race(self):
+        self.assert_wait_race_condition("select.kqueue", select.kqueue)
+
+    def assert_notification_without_immediate_reap(self, patch_target):
+        # Verify fallback to busy polling when poll() / kqueue()
+        # succeeds, but waitpid(pid, WNOHANG) returns (0, 0).
+        def waitpid_wrapper(pid, flags):
+            nonlocal ncalls
+            ncalls += 1
+            if ncalls == 1:
+                return (0, 0)
+            return real_waitpid(pid, flags)
+
+        ncalls = 0
+        real_waitpid = os.waitpid
+        with mock.patch.object(subprocess.Popen, patch_target, return_value=True) as m1:
+            with mock.patch("os.waitpid", side_effect=waitpid_wrapper) as m2:
+                p = subprocess.Popen([sys.executable,
+                                      "-c", "import time; time.sleep(0.3)"])
+                with self.assertRaises(subprocess.TimeoutExpired):
+                    p.wait(timeout=0.0001)
+                self.assertEqual(p.wait(timeout=support.SHORT_TIMEOUT), 0)
+        assert m1.called
+        assert m2.called
+
+    @unittest.skipIf(not CAN_USE_PIDFD_OPEN, reason="needs pidfd_open()")
+    def test_pidfd_open_notification_without_immediate_reap(self):
+        self.assert_notification_without_immediate_reap("_wait_pidfd")
+
+    @unittest.skipIf(not CAN_USE_KQUEUE, reason="needs kqueue() for proc")
+    def test_kqueue_notification_without_immediate_reap(self):
+        self.assert_notification_without_immediate_reap("_wait_kqueue")
+
+    @unittest.skipUnless(
+        CAN_USE_PIDFD_OPEN or CAN_USE_KQUEUE,
+        "fast wait mechanism not available"
+    )
+    def test_fast_path_avoid_busy_loop(self):
+        # assert that the busy loop is not called as long as the fast
+        # wait is available
+        with mock.patch('time.sleep') as m:
+            p = subprocess.Popen([sys.executable,
+                                  "-c", "import time; time.sleep(0.3)"])
+            with self.assertRaises(subprocess.TimeoutExpired):
+                p.wait(timeout=0.0001)
+            self.assertEqual(p.wait(timeout=support.LONG_TIMEOUT), 0)
+        assert not m.called
+
 if __name__ == "__main__":
     unittest.main()
diff --git a/Misc/NEWS.d/next/Library/2026-01-19-16-45-16.gh-issue-83069.0TaeH9.rst b/Misc/NEWS.d/next/Library/2026-01-19-16-45-16.gh-issue-83069.0TaeH9.rst
new file mode 100644
index 00000000000000..7fa365c8485e14
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-01-19-16-45-16.gh-issue-83069.0TaeH9.rst
@@ -0,0 +1,7 @@
+:meth:`subprocess.Popen.wait`: when ``timeout`` is not ``None``, an efficient
+event-driven mechanism now waits for process termination, if available. Linux
+≥= 5.3 uses :func:`os.pidfd_open` + :func:`select.poll`. macOS and other BSD
+variants use :func:`select.kqueue` + ``KQ_FILTER_PROC`` + ``KQ_NOTE_EXIT``.
+Windows keeps using ``WaitForSingleObject`` (unchanged). If none of these
+mechanisms are available, the function falls back to the traditional busy loop
+(non-blocking call and short sleeps). Patch by Giampaolo Rodola.