diff --git a/Include/internal/pycore_opcode_metadata.h b/Include/internal/pycore_opcode_metadata.h
index 947e0e58868e1d..ccd10e90f0c0a3 100644
--- a/Include/internal/pycore_opcode_metadata.h
+++ b/Include/internal/pycore_opcode_metadata.h
@@ -1082,7 +1082,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [BINARY_OP_ADD_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG },
     [BINARY_OP_ADD_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_ADD_UNICODE] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG },
-    [BINARY_OP_EXTEND] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG },
+    [BINARY_OP_EXTEND] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_INPLACE_ADD_UNICODE] = { true, INSTR_FMT_IXC0000, HAS_LOCAL_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_MULTIPLY_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG },
     [BINARY_OP_MULTIPLY_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
diff --git a/Include/internal/pycore_uop_metadata.h b/Include/internal/pycore_uop_metadata.h
index 912b1e56692e1c..2166a6900f120a 100644
--- a/Include/internal/pycore_uop_metadata.h
+++ b/Include/internal/pycore_uop_metadata.h
@@ -95,7 +95,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_BINARY_OP_ADD_UNICODE] = HAS_ERROR_FLAG | HAS_PURE_FLAG,
     [_BINARY_OP_INPLACE_ADD_UNICODE] = HAS_LOCAL_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_GUARD_BINARY_OP_EXTEND] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
-    [_BINARY_OP_EXTEND] = HAS_ESCAPES_FLAG | HAS_PURE_FLAG,
+    [_BINARY_OP_EXTEND] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG | HAS_PURE_FLAG,
     [_BINARY_SLICE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_SLICE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_OP_SUBSCR_LIST_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst
new file mode 100644
index 00000000000000..716a6e149cf885
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst
@@ -0,0 +1 @@
+Check if the result is ``NULL`` in ``BINARY_OP_EXTENT`` opcode.
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index 70f8ac3cff84f9..78325111374a3f 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -824,6 +824,7 @@ dummy_func(
 
             PyObject *res_o = d->action(left_o, right_o);
             DECREF_INPUTS();
+            ERROR_IF(res_o == NULL);
             res = PyStackRef_FromPyObjectSteal(res_o);
         }
 
diff --git a/Python/executor_cases.c.h b/Python/executor_cases.c.h
index e3f4e5bdb65fd5..9dcd9afe884153 100644
--- a/Python/executor_cases.c.h
+++ b/Python/executor_cases.c.h
@@ -1193,6 +1193,9 @@
             stack_pointer = _PyFrame_GetStackPointer(frame);
             stack_pointer += -2;
             assert(WITHIN_STACK_BOUNDS());
+            if (res_o == NULL) {
+                JUMP_TO_ERROR();
+            }
             res = PyStackRef_FromPyObjectSteal(res_o);
             stack_pointer[0] = res;
             stack_pointer += 1;
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index f2b99365772f4d..20b5c4b3f497a9 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -315,6 +315,9 @@
                 stack_pointer = _PyFrame_GetStackPointer(frame);
                 stack_pointer += -2;
                 assert(WITHIN_STACK_BOUNDS());
+                if (res_o == NULL) {
+                    JUMP_TO_LABEL(error);
+                }
                 res = PyStackRef_FromPyObjectSteal(res_o);
             }
             stack_pointer[0] = res;