diff --git a/Include/internal/pycore_opcode_metadata.h b/Include/internal/pycore_opcode_metadata.h
index e3f7f5a6f0bb16..ce6324d0a8e0b9 100644
--- a/Include/internal/pycore_opcode_metadata.h
+++ b/Include/internal/pycore_opcode_metadata.h
@@ -1094,7 +1094,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [BINARY_OP_ADD_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG },
     [BINARY_OP_ADD_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG },
     [BINARY_OP_ADD_UNICODE] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG },
-    [BINARY_OP_EXTEND] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG },
+    [BINARY_OP_EXTEND] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_INPLACE_ADD_UNICODE] = { true, INSTR_FMT_IXC0000, HAS_LOCAL_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_MULTIPLY_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG },
     [BINARY_OP_MULTIPLY_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG },
diff --git a/Include/internal/pycore_uop_metadata.h b/Include/internal/pycore_uop_metadata.h
index 7989c2f33662e4..6398448d5faece 100644
--- a/Include/internal/pycore_uop_metadata.h
+++ b/Include/internal/pycore_uop_metadata.h
@@ -115,7 +115,7 @@ const uint32_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_BINARY_OP_ADD_UNICODE] = HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_PURE_FLAG,
     [_BINARY_OP_INPLACE_ADD_UNICODE] = HAS_LOCAL_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_GUARD_BINARY_OP_EXTEND] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
-    [_BINARY_OP_EXTEND] = HAS_ESCAPES_FLAG,
+    [_BINARY_OP_EXTEND] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_SLICE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_SLICE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_OP_SUBSCR_LIST_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst
new file mode 100644
index 00000000000000..716a6e149cf885
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-01-19-02-33-45.gh-issue-144012.wVEEWs.rst
@@ -0,0 +1 @@
+Check if the result is ``NULL`` in ``BINARY_OP_EXTENT`` opcode.
diff --git a/Modules/_testinternalcapi/test_cases.c.h b/Modules/_testinternalcapi/test_cases.c.h
index fb584314ef40bc..c02d236fc3e8ac 100644
--- a/Modules/_testinternalcapi/test_cases.c.h
+++ b/Modules/_testinternalcapi/test_cases.c.h
@@ -359,6 +359,9 @@
                 stack_pointer = _PyFrame_GetStackPointer(frame);
                 stack_pointer += -2;
                 ASSERT_WITHIN_STACK_BOUNDS(__FILE__, __LINE__);
+                if (res_o == NULL) {
+                    JUMP_TO_LABEL(error);
+                }
                 res = PyStackRef_FromPyObjectSteal(res_o);
             }
             stack_pointer[0] = res;
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index 9058a5210e50f9..5f2461df8e672c 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -839,6 +839,7 @@ dummy_func(
 
             PyObject *res_o = d->action(left_o, right_o);
             DECREF_INPUTS();
+            ERROR_IF(res_o == NULL);
             res = PyStackRef_FromPyObjectSteal(res_o);
         }
 
diff --git a/Python/executor_cases.c.h b/Python/executor_cases.c.h
index 6469deb238f5b0..8f9b62b0bab6ab 100644
--- a/Python/executor_cases.c.h
+++ b/Python/executor_cases.c.h
@@ -5176,6 +5176,10 @@
             stack_pointer = _PyFrame_GetStackPointer(frame);
             stack_pointer += -2;
             ASSERT_WITHIN_STACK_BOUNDS(__FILE__, __LINE__);
+            if (res_o == NULL) {
+                SET_CURRENT_CACHED_VALUES(0);
+                JUMP_TO_ERROR();
+            }
             res = PyStackRef_FromPyObjectSteal(res_o);
             _tos_cache0 = res;
             _tos_cache1 = PyStackRef_ZERO_BITS;
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index b5ae600c095e67..194fbe4f268cb4 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -359,6 +359,9 @@
                 stack_pointer = _PyFrame_GetStackPointer(frame);
                 stack_pointer += -2;
                 ASSERT_WITHIN_STACK_BOUNDS(__FILE__, __LINE__);
+                if (res_o == NULL) {
+                    JUMP_TO_LABEL(error);
+                }
                 res = PyStackRef_FromPyObjectSteal(res_o);
             }
             stack_pointer[0] = res;