diff --git a/dd-java-agent/appsec/build.gradle b/dd-java-agent/appsec/build.gradle
index a9bb2b1b001..34a9c2cc088 100644
--- a/dd-java-agent/appsec/build.gradle
+++ b/dd-java-agent/appsec/build.gradle
@@ -15,6 +15,7 @@ dependencies {
   implementation project(':internal-api')
   implementation project(':communication')
   implementation project(':telemetry')
+  implementation project(':dd-trace-core')
   implementation group: 'io.sqreen', name: 'libsqreen', version: '17.3.0'
   implementation libs.moshi
 
diff --git a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/api/security/ApiSecuritySamplerImpl.java b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/api/security/ApiSecuritySamplerImpl.java
index ce6dab75ae0..2540be7b42d 100644
--- a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/api/security/ApiSecuritySamplerImpl.java
+++ b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/api/security/ApiSecuritySamplerImpl.java
@@ -57,10 +57,26 @@ public ApiSecuritySamplerImpl(
 
   @Override
   public boolean preSampleRequest(final @Nonnull AppSecRequestContext ctx) {
-    final String route = ctx.getRoute();
+    String route = ctx.getRoute();
+
+    // If route is absent, use http.endpoint as fallback (RFC-1076)
     if (route == null) {
-      return false;
+      // Don't sample blocked requests - they represent attacks, not valid API endpoints
+      if (ctx.isWafBlocked()) {
+        return false;
+      }
+      final int statusCode = ctx.getResponseStatus();
+      // Don't use endpoint for 404 responses as a failsafe
+      if (statusCode == 404) {
+        return false;
+      }
+      // Try to get or compute the endpoint
+      route = ctx.getOrComputeEndpoint();
+      if (route == null) {
+        return false;
+      }
     }
+
     final String method = ctx.getMethod();
     if (method == null) {
       return false;
diff --git a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/AppSecRequestContext.java b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/AppSecRequestContext.java
index 2b197756697..b0c0c0386a1 100644
--- a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/AppSecRequestContext.java
+++ b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/AppSecRequestContext.java
@@ -120,6 +120,9 @@ public class AppSecRequestContext implements DataBundle, Closeable {
   private String method;
   private String savedRawURI;
   private String route;
+  private String httpUrl;
+  private String endpoint;
+  private boolean endpointComputed = false;
   private final Map<String, List<String>> requestHeaders = new LinkedHashMap<>();
   private final Map<String, List<String>> responseHeaders = new LinkedHashMap<>();
   private volatile Map<String, List<String>> collectedCookies;
@@ -423,6 +426,45 @@ public void setRoute(String route) {
     this.route = route;
   }
 
+  public String getHttpUrl() {
+    return httpUrl;
+  }
+
+  public void setHttpUrl(String httpUrl) {
+    this.httpUrl = httpUrl;
+  }
+
+  /**
+   * Gets or computes the http.endpoint for this request. The endpoint is computed lazily on first
+   * access and cached to avoid recomputation.
+   *
+   * @return the http.endpoint value, or null if it cannot be computed
+   */
+  public String getOrComputeEndpoint() {
+    if (!endpointComputed) {
+      if (httpUrl != null && !httpUrl.isEmpty()) {
+        try {
+          endpoint = datadog.trace.core.endpoint.EndpointResolver.computeEndpoint(httpUrl);
+        } catch (Exception e) {
+          endpoint = null;
+        }
+      }
+      endpointComputed = true;
+    }
+    return endpoint;
+  }
+
+  /**
+   * Sets the endpoint directly without computing it. This is useful when the endpoint has already
+   * been computed elsewhere.
+   *
+   * @param endpoint the endpoint value to set
+   */
+  public void setEndpoint(String endpoint) {
+    this.endpoint = endpoint;
+    this.endpointComputed = true;
+  }
+
   public void setKeepOpenForApiSecurityPostProcessing(final boolean flag) {
     this.keepOpenForApiSecurityPostProcessing = flag;
   }
diff --git a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/GatewayBridge.java b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/GatewayBridge.java
index 174f977ff21..f04c53df2f5 100644
--- a/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/GatewayBridge.java
+++ b/dd-java-agent/appsec/src/main/java/com/datadog/appsec/gateway/GatewayBridge.java
@@ -949,11 +949,16 @@ private NoopFlow onRequestEnded(RequestContext ctx_, IGSpanInfo spanInfo) {
   private boolean maybeSampleForApiSecurity(
       AppSecRequestContext ctx, IGSpanInfo spanInfo, Map<String, Object> tags) {
     log.debug("Checking API Security for end of request handler on span: {}", spanInfo.getSpanId());
-    // API Security sampling requires http.route tag.
+    // API Security sampling requires http.route tag or http.url for endpoint inference.
     final Object route = tags.get(Tags.HTTP_ROUTE);
     if (route != null) {
       ctx.setRoute(route.toString());
     }
+    // Pass http.url to enable endpoint inference when route is absent
+    final Object url = tags.get(Tags.HTTP_URL);
+    if (url != null) {
+      ctx.setHttpUrl(url.toString());
+    }
     ApiSecuritySampler requestSampler = requestSamplerSupplier.get();
     return requestSampler.preSampleRequest(ctx);
   }
diff --git a/dd-java-agent/appsec/src/test/groovy/com/datadog/appsec/api/security/ApiSecuritySamplerTest.groovy b/dd-java-agent/appsec/src/test/groovy/com/datadog/appsec/api/security/ApiSecuritySamplerTest.groovy
index 029d23c5a2f..d5d116640f5 100644
--- a/dd-java-agent/appsec/src/test/groovy/com/datadog/appsec/api/security/ApiSecuritySamplerTest.groovy
+++ b/dd-java-agent/appsec/src/test/groovy/com/datadog/appsec/api/security/ApiSecuritySamplerTest.groovy
@@ -79,7 +79,7 @@ class ApiSecuritySamplerTest extends DDSpecification {
     preSampled3
   }
 
-  void 'preSampleRequest with null route'() {
+  void 'preSampleRequest with null route and no URL'() {
     given:
     def ctx = createContext(null, 'GET', 200)
     def sampler = new ApiSecuritySamplerImpl()
@@ -91,6 +91,113 @@ class ApiSecuritySamplerTest extends DDSpecification {
     !preSampled
   }
 
+  void 'preSampleRequest with null route but valid URL uses endpoint fallback'() {
+    given:
+    def ctx = createContextWithUrl(null, 'GET', 200, 'http://localhost:8080/api/users/123')
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled = sampler.preSampleRequest(ctx)
+
+    then:
+    preSampled
+    ctx.getOrComputeEndpoint() != null
+    ctx.getApiSecurityEndpointHash() != null
+  }
+
+  void 'preSampleRequest with null route and 404 status does not sample'() {
+    given:
+    def ctx = createContextWithUrl(null, 'GET', 404, 'http://localhost:8080/unknown/path')
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled = sampler.preSampleRequest(ctx)
+
+    then:
+    !preSampled
+  }
+
+  void 'preSampleRequest with null route and blocked request does not sample'() {
+    given:
+    def ctx = createContextWithUrl(null, 'GET', 403, 'http://localhost:8080/admin/users')
+    ctx.setWafBlocked()  // Request was blocked by AppSec
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled = sampler.preSampleRequest(ctx)
+
+    then:
+    !preSampled  // Blocked requests should not be sampled
+  }
+
+  void 'preSampleRequest with null route and 403 non-blocked API does sample'() {
+    given:
+    def ctx = createContextWithUrl(null, 'GET', 403, 'http://localhost:8080/api/forbidden-resource')
+    // NOT calling setWafBlocked() - this is a legitimate API that returns 403
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled = sampler.preSampleRequest(ctx)
+
+    then:
+    preSampled  // Legitimate APIs that return 403 should be sampled
+    ctx.getOrComputeEndpoint() != null
+    ctx.getApiSecurityEndpointHash() != null
+  }
+
+  void 'preSampleRequest with null route and blocked request with different status codes does not sample'() {
+    given:
+    def ctx200 = createContextWithUrl(null, 'GET', 200, 'http://localhost:8080/attack')
+    ctx200.setWafBlocked()
+    def ctx500 = createContextWithUrl(null, 'GET', 500, 'http://localhost:8080/attack')
+    ctx500.setWafBlocked()
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled200 = sampler.preSampleRequest(ctx200)
+    def preSampled500 = sampler.preSampleRequest(ctx500)
+
+    then:
+    !preSampled200  // Blocked requests should not be sampled regardless of status code
+    !preSampled500
+  }
+
+  void 'second request with same endpoint is not sampled'() {
+    given:
+    def ctx1 = createContextWithUrl(null, 'GET', 200, 'http://localhost:8080/api/users/123')
+    def ctx2 = createContextWithUrl(null, 'GET', 200, 'http://localhost:8080/api/users/456')
+    def sampler = new ApiSecuritySamplerImpl()
+
+    when:
+    def preSampled1 = sampler.preSampleRequest(ctx1)
+    ctx1.setKeepOpenForApiSecurityPostProcessing(true)
+    def sampled1 = sampler.sampleRequest(ctx1)
+    sampler.releaseOne()
+
+    then:
+    preSampled1
+    sampled1
+
+    when:
+    def preSampled2 = sampler.preSampleRequest(ctx2)
+
+    then:
+    !preSampled2 // Same endpoint pattern, so not sampled
+  }
+
+  void 'endpoint is computed only once'() {
+    given:
+    def ctx = createContextWithUrl(null, 'GET', 200, 'http://localhost:8080/api/users/123')
+
+    when:
+    def endpoint1 = ctx.getOrComputeEndpoint()
+    def endpoint2 = ctx.getOrComputeEndpoint()
+
+    then:
+    endpoint1 != null
+    endpoint1 == endpoint2
+  }
+
   void 'preSampleRequest with null method'() {
     given:
     def ctx = createContext('route1', null, 200)
@@ -371,4 +478,13 @@ class ApiSecuritySamplerTest extends DDSpecification {
     ctx.setResponseStatus(statusCode)
     ctx
   }
+
+  private static AppSecRequestContext createContextWithUrl(final String route, final String method, int statusCode, String url) {
+    final AppSecRequestContext ctx = new AppSecRequestContext()
+    ctx.setRoute(route)
+    ctx.setMethod(method)
+    ctx.setResponseStatus(statusCode)
+    ctx.setHttpUrl(url)
+    ctx
+  }
 }